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lic reprogramming that results from Myc deregulation is exemplified by the "Warburg effect"whereby ATP originating from mitochondrial sources is largely supplanted by that derived from glycolysis, even in oxygen-rich environments . Among the advantages believed to become afforded by the switch to this less efficient mode of energy generation can be a redirecting of TCA intermediates away from ATP
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ted herein indicate that chloroquine reduces the clinical course of EAE. We propose that this effect is due to the expansion of regulatory T cells in the spleen, which reduces the specific cellular response in the periphery. CQ may also affect other T cell subtypes that contribute to the reduced EAE severity. Interestingly, Treg cells also migrate to the CNS to reduce local inflammation and promot
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